Solution for injection
Ivermectin 10 mg/ml (1% w/v) – clorsulon 100 mg/ml (10% w/v)
Ivermectin belongs to the family of avermectins, endectocides of the class of macrocyclic lactones.
Ivermectin acts in two ways, by interference with neural transmission and the opening of chloride ion channels. Ivermectin increases the release of gamma amino butyric acid (GABA) close to the post-synaptic receptors inducing the opening of the chloride ion channels and decrease in cellular function. There is also evidence of ivermectin acting directly and independant of GABA. The opening of the pre-synaptic chloride ion channels is followed by an efflux of chloride ions and a depolarization of the terminal nerve. These effects interfere with normal neurotransmission between nerves and muscles resulting in paralysis and eventually death.
Clorsulon is a sulfonamide given as a SC injection for cattle, in combination with ivermectin. In plasma, clorsulon is bound to protein and, when ingested by liver flukes, inhibits enzymes of the glycolytic pathway. Clorsulon has a wide safety margin.
For the treatment and control of gastro-intestinal nematodes, lungworms, flukes, eyeworms, warbles, mites and lice (as shown below) of beef and non-lactating dairy cattle.
Gastro-intestinal worms: (adult and fourth stage larvae): Ostertagia ostertagi(including inhibited larval stages), Ostertagia lyrata, Haemonchus placei,Trichostrongylus axei, Thrichostrongylus colubriformis, Cooperia oncophora,Cooperia punctata, Cooperia pectinata, Bunostomum phlebotomum,Oesophagostomum radiatum, Strongyloides papillosus (adult), Nematodirus helvetianus (adult), Nematodirus spathiger (adult) and Trichuris spp (adult).
Lungworms: (adult and fourth stage larvae): Dictyocaulus viviparus
Eyeworms: (adult): Thelazia spp.
Flukes: (adult): Fasciola hepatica, Fasciola gigantic
Warbles: (parasitic stages): Hypoderma bovis and H. lineatum
Mites: Psoroptes bovis, Sarcoptes scabiei var. bovis
Sucking lice: Linognathus vituli, Haematopinus eurysternus andSolenopotes capillatus.
May also be used as an aid in the control of the mange mite Chorioptes bovis and biting lice (Damalinia bovis), but complete elimination may not occur.
IVERMECTIN 10 PLUS injection should not be used in other species as severe adverse reactions, including fatalities may occur.
DOSAGE AND MODE OF ADMINISTRATION
1ml per 50 kg bodyweight (based on the recommended dose of 200 mcg ivermectin per kg bodyweight), administered by subcutaneous injection in front of, or behind the shoulder using aseptic technique. A sterile 17 gauge x half inch (15-20 mm) needle is recommended.
Transitory discomfort has been observed in some cattle following subcutaneous administration. A low incidence of soft tissue swelling at the injection site has been observed. These reactions have disappeared without treatment. Immediately following subcutaneous injection, activity suggesting pain, sometimes intense, but usually transient, has been observed in some sheep.
SPECIAL PRECAUTIONS FOR USE AND WARNINGS
This product is not for intravenous or intramuscular use.
Ivermectin 10 Plus should not be used in other species as severe adverse reactions including fatalities in dogs may occur.
Do not mix with other medicinal products.
Store below 25°C and protect from light.
Keep out of the reach of children.
10 ml, 20 ml, 50 ml, 100 ml and 500 ml multi-dose plastic vials.
Please be aware that product specifications and availability can differ between countries. For detailed information in this regard, please contact us.